![]() ![]() Modern Combat 3 for the BlackBerry PlayBook is unquestionably worth the download and can be found in BlackBerry App World for $2.99. The game also has some of the best graphics I've seen on any mobile platform to date. The game features an AI engine that will keep you guessing as to which way your enemies are going to come from. While there is no multiplayer (just yet), Gameloft has done a fantastic job bringing Modern Combat 3 to the BlackBerry PlayBook. Visually unattractive loading screen (not present on other Gameloft games).No multiplayer support while other platforms have it.Ability to place controls anywhere on the screen.Proactive and reactive enemy artificial intelligence.In the control settings you can invert the Y-axis, change sensitivity, and select between three different virtual controls layout to give you the competitive edge. Games similar to Ace Combat 3: Electrosphere on RAWG Video game discovery site The most comprehensive database that is powered by personal player. Probably one of the handiest settings is within the control settings page. ![]() Within the game you have access to change the language, sound levels, and also change a wide verity of assisting alterations like aim assist and more. The developers at Gameloft Montréal have provided a plethora of in-game settings to make your gaming experience just a little bit better, because remember in Modern Combat 3 it's between life and death. If you have the controls on their default layout and place your right thumb to the top portion of the screen you often mistakenly throw a grenade, an issue that could be fixed if you could move the location of those controls. There is one thing I noticed while playing Modern Combat 3, and that is the issue with on-screen controls. The overall game play was well done, and was enhanced with character acting that was actually quite good. Modern Combat 3 is a first person shooter that incorporates on-screen controls, cinematic cut scenes and artificial intelligence to carry you through a world where war, is the only option. One thing that games on mobile devices typically lack is the ability to tell a story and keep the user entertained, Modern Combat 3 for the BlackBerry PlayBook changes the norm. From the first cinematic cut scene to the last intense battle, you'll be fully immersed in the characters and the story. Gameloft has done a phenomenal job at creating a captivating storyline that keeps you wanting more. ![]()
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![]() ![]() 1 TGF-β-mediated EMT is associated with proliferative arrest. Overall, these results provide evidences for proliferative arrest coupled to TGF-β-mediated EMT differentiation in Huh7 cells.įig. The protein levels of E-Cad also showed a decrease validating the EMT of Huh7 cells ( Supplementary Figure S2). In accordance to above, analysis of RNA sequencing data from TGF-β exposed Huh7 cells also revealed an elevated expression level of mesenchymal candidate genes like Vimentin and N-Cad coupled to a decreased expression of epithelial cell marker- Epithelial-Cadherin (E-Cad) transcript level ( Supplementary Figure S1). Moreover, a clear enhancement in fluorescence signal and spatial re-arrangement of Vimentin was observed post TGF-β treatment ( Fig. Similar results were also observed at the protein level for N-Cad and Vimentin ( Fig. To further validate a differentiated phenotype, we analysed the transcript levels of the well-acknowledged EMT markers like Neural-Cadherin ( N-Cad) and Vimentin which also showed a significant increase with TGF-β exposure ( Fig. Importantly, the cortical actin network also showed considerable alterations upon cytokine treatment. As expected, the Huh7 cells attained a comparatively elongated phenotype post TGF-β exposure reflective of their probable mesenchymal differentiation, as observed through confocal imaging with F-actin phalloidin staining ( Fig. We initially monitored the overall morphology of the cells after treatment. This putative proliferative arrest was coupled to the canonical feature of TGF-β-induced effect- EMT. In addition, a significant decrease in expression of both CCNB1 and Cyclin A2 (CCNA2) was observed through real-time PCR suggesting a deregulation of cell cycle in Huh7 cells after exposure to the cytokine- TGF-β ( Fig. On the similar note, deep sequencing of total RNA from TGF-β exposed Huh7 cells revealed a 2-fold decrease in transcript level of cell cycle associated genes like, Cyclin B1 transcript (CCNB1) ( Fig. This was coupled with a significant decrease in protein expression of cellular proliferation associated molecular markers like, Proliferating Cell Nuclear Antigen (PCNA) after TGF-β administration ( Fig. ![]() Importantly, in our study, TGF-β exposure in Huh7 cells led to a considerable decrease in cell density in comparison to the untreated cells as observed through Crystal Violet staining ( Fig. Our results provide better understanding of cellular invasive features which can lead to development of novel therapeutic strategies. Overall, our findings reflect that HCC cells undergoing EMT, attain cytostasis and modulate metabolic demands to efficiently facilitate the EMT differentiation switch, and these events are regulated at the epigenomic level through TGF-β-mediated signalling. Importantly, TGF-β-downstream signalling mediator- SMAD and chromatin repressive complex member-enhancer of zeste homolog 2 (EZH2) were found to co-immunoprecipitate and were required for the above effects. An overall increase in total histone repressive mark (H3K27me3) associated with a specific enrichment of H3K27me3 at the upstream promoter region of CCNA2 and GOT1 was observed after TGF-β exposure, leading to their down-regulation. TGF-β resulted in down-regulation of cell cycle-associated transcripts, like Cyclin A2 (CCNA2), and metabolic genes, like Glutamic-oxaloacetic transaminase 1 (GOT1) through epigenetic silencing. ![]() Interestingly, EMT triggered by TGF-β was found to be associated with cytostasis and altered cellular metabolism. Therefore, as part of this study, we treated HCC cells with TGF-β and characterized the cellular processes associated with EMT. In spite of its clinical relevance, the cellular events associated with TGF-β-induced EMT and its molecular regulation is poorly elucidated. One of its classical functions involve facilitation of epithelial to mesenchymal transition (EMT), in tumour cells, promoting an invasive phenotype. In this context, one of the major cytokines present in the HCC tumour milieu is the transforming growth factor-β (TGF-β). A better understanding of the cytokine functions and their contributions to disease development is key to design of future therapeutic strategies and reduction of global HCC burden. Hepatocellular carcinoma (HCC) frequently unfolds under an inflammatory condition, which is a hub for a plethora of cytokines. ![]() ![]() ![]() I don’t recommend using any products that use adhesive. Although they might be better off used to block off dangerous areas of the house that don’t have doors, like the tops of staircases. If you have a baby gate around the house, setting it up in a doorway that you want sectioned off is a good solution. They keep the door securely shut, and even the most stubborn of toddlers won’t be able to get it open no matter how hard they try.Īn upside to the material used is that in the case of an emergency (heaven forbid), an adult could easily break the lock quickly.Īll in all, if you’re looking for a way to baby-proof your doors, I think this is the best option. The plastic they use does seem somewhat flimsy, but you shouldn’t have any trouble with that. You can buy them online, and have them shipped to your home. They’re easy to install, and you can do it in less than 5 minutes.You can open the lock from either side of the door, which is something unique in these door baby-proofing products.They’re easy to lock and unlock you just pull on a latch.There’s no possible way your child could reach it, so they can’t circumvent it unlike locks that go on the doorknob. I recommend it over other solutions for a few reasons: The product I recommend that works for most doors is the Child Proof Deluxe Door Top Lock ( click here to check price on Amazon). There are tons of different products for baby-proofing your door knobs, and there’s really no one “best” solution for all homes. My recommendations: doorknob baby-proofing products Some of them can be a royal pain in the you-know-what if you have to disable them constantly to get through. The second question is whether the lock is convenient to disable for you. Don’t just assume that because you put a baby-proofing lock on the door that they’re not going to get through it! When choosing one for your home, the first real question in is whether or not your child is observant and capable of circumventing the lock.īelieve me, you’d be amazed at how intelligent a crafty toddler can be. ![]() One option is to change out all door knobs that don’t lock with those that do have a locking mechanism, but that can be costly and really not a great option unless you didn’t really like your existing doorknobs to begin with.īaby-proofing products for doorknobs exist in a variety of formats. If your doors already have locks, the easiest way to baby-proof them is to simply lock them every time you close them. The way to baby-proof doors is to simply make it so that they can’t be opened by the inquisitive toddler. How to: baby-proofing doorknobs to keep them shut In this guide, I will tell you how to deal with both of these issues and make all of the doors in your home perfectly baby-proofed and safe for your little one. Second of all, sometimes you just don’t want children to be able to open doors leading to dangerous areas that they should be kept away from. A DIY solution to preventing pinched fingersĭoors can be a surprisingly dangerous part of the home for a curious child.įirst of all, the hinges of the door can be very pinchy, and injuries to delicate fingers are known to happen with improperly baby-proofed doors.My recommendations: doorknob baby-proofing products.How to: baby-proofing doorknobs to keep them shut. ![]() ![]() ![]() Automate complex, multi-layered 3D animation with ease, control layer instances, without writing expressions, and create dynamic 'falling domino' or 'follow-the-leader' animations. 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Red Giant Trapcode Suite 14 Review:Įssentially Red Giant is a software company made up of artists and technologists who collaborate on the creation of unique software tools for filmmakers, editors, visual effects artists, and motion designers. Developer develop Red Giant Trapcode Suite 14 Serial Code for developers, artists and graphics designer.īasically Red Giant Trapcode Suite is a complete set of 11 tools for 3D motion graphics and visual effects. Red Giant Trapcode Suite 2023 2 Crack is Here 2023 Tested. Red Giant software tools are primarily plug-ins for video host applications, such as Adobe Premiere Pro, Adobe after Effects, and Final Cut Pro, DaVinci Resolve, Sony Vegas and more. Get it on Amazon 14 The Gentleman s Guide to Vice and Virtue by Mackenzi Lee View this photo. 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Later in the track, when Oh Wonder singer Josephine Vander Gucht’s original vocals enter the mix, we step into Uzi’s shoes, and the solace she brought him. “The Way Life Goes” stands apart in Uzi’s discography because it’s a rare intimate ballad from an artist who can sometimes feel like he’s rapping at arm’s distance. Great songs often take on new lives as samples and covers, but rarely are they folded into a fan’s work so literally. “I was listening to this song,” Uzi says before the first chorus, which he lifts directly from the London duo Oh Wonder’s original, “Landslide.” He adds, “It go like: I know it hurts sometimes, but you’ll get over it.” ![]() But when you hear the actual song, another meta-narrative reveals itself: Uzi is still listening to the track as he records his version. ![]() On the surface, “The Way Life Goes” has a familiar story behind it: An avid music fan samples a little-known indie-pop track and flips it into a hit. Those dated criticisms of Uzi held no weight after “XO Tour Llif3.” It’s more than a song, more than a hit: It’s a pivotal moment in popular music. The combination was head-scratching at first then, suddenly, everyone was wailing along to “Push me to the edge/All my friends are dead.” Uzi yelped his pain away on the chorus and dug into his verses with the passion and intensity of the student of rap he is. But Uzi’s persona elevates everything around him: He raps about wanting to die, like so many rappers before, but does it with a shoulder-shimmying bounce. Produced by JW Lucas and TM88, a member of the influential Atlanta production crew 808 Mafia, it has a classic drum pattern and a sinister melody. “XO Tour Llif3” could have sounded like a typical ATL record. But a dive beyond the surface of Uzi’s catalog reveals that he’s always been more traditional than naysayers claimed he just added a new type of flair to the street-rapper molds of the past. Whether it was his bright sing-rap vocals or his colorful fashion choices, Uzi was viewed as a step away from tradition. –Alphonse Pierreīefore “XO Tour Llif3,” rap purists insisted Uzi and his SoundCloud peers were outsiders in hip-hop. Here, we trace his career so far with a chronological rundown of our 20 favorite Lil Uzi Vert songs and features. He has cemented himself as a uniquely personal artist with the power to capture the complexities of his young fans’ lives. Every release of a Lil Uzi mixtape or album-from Luv Is Rage to this year’s immense Eternal Atake-stops the always-spinning hip-hop world in its tracks. Not like they had a choice: His impact is undeniable. It’s taken some time, but by now, the hip-hop world has fully come around to Uzi. But Uzi always remained unbothered by the noise around him. Demeaning umbrella terms like “SoundCloud rap” and “mumble rap” were used by fans and press to knock him down a peg. But his increasing fame made him a target for criticism from rap fans who had a difficult time adjusting to Uzi’s nontraditional take on the genre they loved. Through it all, he put forth the whimsical persona of a guy who was interested only in fast cars and flashy clothes, unless he was completely heartbroken (which was often). From there, his profile continued to rise: He collaborated with Playboi Carti, Young Thug, and Future, and released impactful tapes, albums, loosies, and more. ![]() ![]() ![]()
![]() “Usher: My Way – The Las Vegas Residency” – Usher “REFLECTION: The Las Vegas Residency” – Carrie Underwood ![]() “An Evening With Silk Sonic” – Bruno Mars, Anderson. The Weeknd Favorite Residency: *Socially Voted Category ![]() “Untrapped: The Story of Lil Baby” – Lil Baby Favorite Tour Style: *Socially Voted Category ![]() “Shania Twain: Not Just a Girl” – Shania Twain “Selena Gomez: My Mind & Me” – Selena Gomez “Niall Horan’s Homecoming: The Road To Mullingar With Lewis Capaldi” – Niall Horan + Lewis Capaldi “World’s Smallest Violin” – AJR Favorite Documentary: *Socially Voted Category YUNGBLUD – Tom Pallant TikTok Bop of the Year: *Socially Voted Category Yung Gravy Favorite Tour Photographer: *Socially Voted Category “Swifties” – Taylor Swift Social Star Award: *Socially Voted Category “Yet To Come” – BTS Best Fan Army: *Socially Voted Category “Don’t You Worry” – Black Eyed Peas, Shakira, David Guetta “We Don’t Talk About Bruno” – Lin-Manuel Miranda performed by the Cast of Encanto Best Music Video: *Socially Voted Category Venesti Best Lyrics: *Socially Voted Category “Ya Supérame” – Grupo Firme Regional Mexican Artist of the Year “Cómo Te Olvido” – La Arrolladora Banda El Limón de René Camacho Rauw Alejandro Regional Mexican Song of the Year “Provenza” – Karol G Latin Pop/Reggaeton Artist of the Year “El Incomprendido” – Farruko/ Víctor Cárdenas/ DJ Adoni Tiësto Latin Pop/Reggaeton Song of The Year “I’m Good (Blue)” – David Guetta & Bebe Rexha Dance Artist Of The Year “Heaven Takes You Home” – Swedish House Mafia & Connie Constance “Taking Me Back” – Jack White Rock Artist Of The Year Weezer Best New Artist (Alternative & Rock) “Running Up That Hill (A Deal With God)” – Kate Bush Alternative Artist Of The Year “Enemy (from the series Arcane League Of Legends)” – Imagine Dragons “Smokin Out The Window” – Bruno Mars, Anderson. Priscilla Block Afrobeats Artist Of The Year “Wasted On You” – Morgan Wallen Country Artist Of The Year “She Had Me At Heads Carolina” – Cole Swindell ![]() “Sweetest Pie” – Megan Thee Stallion & Dua Lipa “One Right Now” – Post Malone & The Weeknd “I Like You (A Happier Song)” – Post Malone feat. “Half Of My Hometown” – Kelsea Ballerini feat. “Drunk (And I Don’t Wanna Go Home)” – Elle King & Miranda Lambert “Woman” – Doja Cat Best Duo/Group Of The Year “Industry Baby” – Lil Nas X & Jack Harlow “Enemy (from the series Arcane League of Legends)” – Imagine Dragons In a statement, Tom Poleman, President and Chief Programming Officer for iHeartMedia, said this prior to the ceremony, “It’s been a great year for music with so many inspiring hits, we can’t wait to celebrate these artists and songs at the 2023 iHeartRadio Music Awards.” Other notable winners included SZA, BTS, and Tems, all of which took home multiple awards. Although he couldn’t attend the ceremony, the recording artist did send in a thank you video. The evening’s second biggest winner was Harry Styles taking home three awards (Artist of the Year, Favorite Tour Style, Favorite Residency). The songwriter set the record for the most wins, taking home a total of six awards, including the Innovator Award, which was presented to her by Phoebe Bridgers, Song Of The Year, Best Pop Album, Best Lyrics, TikTok Bop Of The Year, and Favorite Use of A Sample. Taking a break from her The Eras Tour, the “Lavender Haze” singer sporting a hooded, bezzled, long-sleeved jumpsuit was certainly dressed for the trophy heist she pulled off tonight (March 27). Tonight’s iHeartRadio Music Awards was all about Taylor Swift. ![]() ![]() ![]() You can do this with a Hex Bubble, which is able to retain the Axe’s freeze for about 10 seconds. Now comes the second conundrum: you have to freeze both of the gears on the left and right sides of the shield to keep the gate from closing. Yank to shield to the right to get it into position, then man the wheel crank and turn it to open the gate. This will stop the shield from rolling too far! Loot the Hacksilver Chest, then drop down the edge of the roof back to solid ground. Yank it to the left, and it’ll now be sticking out over the edge of the roof. Head through the doorway and get to the stone column you knocked down earlier. Set up another Hex Bubble chain you can set off with the Blades of Chaos’ Blazing Surge to light it. As you approach the door, keep an eye out for the R Rune’s torch above and to the right of it. Next, climb up the left-hand side of the shield to get back up to the left-hand side of the building. This moves it out of the way so you can put the stone column into position. From here, latch onto the left-hand side of the shield and tug it to the left. Head through the open doorway, defeat the Wisps that show up with the help of Hexes, then drop down the side of the building (don’t forget to loot the Coffin for 1 Petrified Bone and 871 Hacksilver). While you can try and move the column with the Blades of Chaos, Tyr’s shield is in the way! At the top, break the black pot to destroy the gold rocks, felling a stone column. ![]() ![]() With that done, yank the shield back to the right, then climb up it to the right-hand side of the ruins. This will reveal the C Rune’s torch: set up a chain of Hex Bubbles using Sigil Arrows and set off a reaction with a Blazing Surge. To begin, latch the Blades of Chaos onto the grapple point on the right-hand side of the shield, then yank it to the left. This requires moving a makeshift stopper into position. The goal is to roll the shield just enough that a hole at the bottom lets you enter the gate of the building. This Nornir Chest is a lengthy one, because you have to complete it while you’re in the middle of solving the Tyr’s Shield puzzle that is the showcase of this area. The N Rune is located in the area between the two staircases of this lower tomb area. This bell rings the longest of the three, so you should hit this one first, then quickly whack the other two bells. The C Rune is to the left of the Nornir Chest it’ll be in a dark chasm to the right of the Mystic Gateway. The R Rune stops ringing the fastest, so it should be the last one you hit. Normally it’s blocked by a gate if that's the case for you, climb up the wall to the left of the Nornir Chest and make your way back around and open the gate from the other side. The R Rune is just to the right of the Nornir Chest. So, you should hit them in a C-N-R order. The tricky part however is that the Bells ring for differing amounts of time: the C Rune’s bell rings for an extremely long time, while the N and R Rune Bells are very short. The Nornir Chest can be spotted in the back-right corner of the starting room, when you first head down the stairs. Navigation in The Oarsman changes after you’ve climbed back above ground, defeated the Stalker, pulled the chain to move the boat, descended back underground, and opened the gate back to the starting area.įor this reason, we expect that you’ve done all this BEFORE attempting the Nornir Chest. ![]() ![]() ![]()
![]() ![]() ![]() This press release contains forward-looking statements relating to expectations, plans, and prospects including expectations relating to the benefits that will be derived from this transaction. Financial Technology Partners (FT Partners) served as strategic and financial advisor and Morrison & Foerster LLP served as legal counsel to Divvy.Ĭautionary Language Concerning Forward-Looking Statements LLC served as financial advisor and Fenwick & West LLP served as legal counsel to. The brand and quality of service that delivers combined with a great spend management product like Divvy will help us automate the flow of bills and expenses into one.” - John DeLalio, Managing Director, EisnerAmperīill.com intends to provide a financial update on its regularly scheduled fourth quarter earnings call. EisnerAmper’s value proposition is focused on providing efficiency and value to our clients, so they can focus on their business. “Together these products deliver a win-win for our firm and our clients. “The Divvy acquisition is the first time that two really solid products are coming together - the combination has the potential to be industry changing.” - Dan Luthi, COO, Ignite Spot Accounting The result? It saves room in my head and leaves more time for compliance, timelines, and production schedules.” - Hunter Thompson, Head of Operations at Golden Ratio “A key benefit of both products is our ability to have a controlled budget in one place. If it isn’t already, should be a part of every B2B business’ tech stack both for finance and operations.” - Jim Benton, CEO, Chorus.ai I’m excited to see this acquisition as builds an all-in-one financial shop, creating a streamlined solution to manage financial workflows and transactions. Being a distributed workforce across multiple cities and countries, we needed digital solutions that supported our critical back-end functions while also supporting employee perks with the benefits of fund allocations. “ and Divvy have both played a huge role in transforming our office operations while also significantly impacting our employee culture. ![]() I'm excited that two tools that I love are coming together.” - Nik Hurley, Finance Manager, Bloom Credit “ and Divvy are both really easy to use and tailor-made for small businesses. "We see the combination of and Divvy as potentially very valuable to small and mid-sized businesses because it creates a single software company focused on helping them to manage, track and control all their business to business spending versus them having to stitch together a number of point solutions." - Kevin Permenter, Research Manager at IDC With real-time insight into all their B2B spending and access to multiple payment solutions, businesses will be empowered to spend smarter, better manage their budgets and cash flow, and simplify their back-office financial operations. The expanded solution will enable businesses to digitally transform their financial operations and automatically manage accounts payable, accounts receivable, and corporate card spend all in one place. The acquisition of Divvy supports ’s mission to make it simple to connect and do business. Together we achieve that vision faster and are better able to serve business owners and finance leaders.” “We have a shared vision to be the one-stop shop for credit and financial software. “We are excited to join and offer our customers and millions of businesses a comprehensive payments solution that saves them time and money,” said Blake Murray, Divvy CEO and Co-Founder. With the elegant spend management solution that the Divvy team brings, their dedication to serving SMBs, and their passion for driving innovation, together we can accelerate our vision to help SMBs transform, grow, and thrive by automating their financial operations.” “Together, we can help SMBs manage all their B2B spend and workflow with one simple solution, saving them valuable time and money and providing real-time insight into their spend and cash flow. “We are thrilled to welcome the Divvy team to ,” said René Lacerte, CEO and Founder. (NYSE:BILL), a leading provider of cloud-based software that simplifies, digitizes, and automates complex back-office financial operations for small and midsize businesses (SMBs), announced today it has completed its acquisition of Divvy, a leader in spend management, for approximately $2.5 billion in stock and cash. Extends platform with leading spend management capabilitiesĬreates a one-stop shop solution for SMBs to automate their financial operations and manage all their B2B spend ![]() |